natural sciences/physical sciences/optics/laser physics
MSCA-IF-EF-RI - RI – Reintegration panel
Izmir Biomedicine and Genome Center
The figure shows a map of the peak predicted mucosal temperatures during scanning on the x-axis as functions of both laser beam diameter and laser power. The solid white line shows 98% proportional thermal damage calculated based on 60 °C critical temperature from laser irradiation.
The figure shows a flow block diagram of the developed computer model.
Serhat TOZBURUN, PhD
This proposal is an interdisciplinary research action. The objective of the CLEAN project is to develop a novel endoscopic capsule design and to build a prototype endoscopy system using this capsule, which provides local ablation to the superficial layer of target mucosal tissue with sufficient depth to remove abnormal tissue. However, this depth will be shallow enough to avoid the residual effects of therapy within deeper tissue layers.
To develop a computer modelling to mimic the thermal dynamics of the capsule. It is to characterize the total heat energy needed to successfully ablate the lining layer, an adequate sliding speed along the oesophagus, an adequate therapy time for effective thermal target layer ablation, and the amount of thermal injury induced to the various oesophagus layers.
To develop the configuration of the capsule in a computer-aided design program. This original design simply extends the target layer above and away from its underlying layers to achieve a well confined therapeutic effect by delivering vacuum force. With the confinement of therapeutic effect, it is aimed that deeper tissue structures are partially separated from ablation region.
To construct and optimize a prototype-level endoscopy system for pre-clinical ex-vivo tissue trials. A high power, 1380-nm diode laser will be used for the therapeutic photothermal ablation.
To investigate the feasibility of the design and to evaluate the performance of the prototype system in ex-vivo sheep oesophagus model. Tissue samples will be collected for histology examination to validate the performance goals of the device.
Experimental setup. The capsule will be processed from biocompatible material. We will post the latest versions of capsule design and the system after the publication of our research article regarding the CLEAN project.
Figure shows a block diagram of laser power measurement setup connected to electric current. GL: fiber-coupled GRIN lens. NDF: Neutral density filter. D: Detector.
Figure shows a block diagram and results of the knife edge measurement technique used to calculate the diameter and coherence length of the laser beam produced by the diode laser coupled GRIN lens. GL: GRIN lens. D: Detector. R: Sharp edged razor.
Field of science
Call for proposal